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We brought together a peptide studied in preclinical models for its role in gut barrier comfort, clinically researched pre- and probiotics to nourish the microbiome, and targeted tributyrin to deliver butyrate where its needed most

ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

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The AhR resides in the cytoplasm and, upon ligand binding, moves to the nucleus, where it heterodimerizes with the AhR nuclear translocator